S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma
نویسندگان
چکیده
Despite several new therapeutic options, multiple myeloma (MM) patients experience relapses and inevitably become refractory to treatment. Insights into drug resistance mechanisms may lead the development of novel treatment strategies. The S100 family is comprised 21 calcium binding protein members with 17 genes located in 1q21 region, which commonly amplified MM. Dysregulated expression associated tumor initiation, progression inflammation. However, relationship between MM pathogenesis response unknown. In this study, roles were systematically studied at copy number, transcriptional level patients’ survival response. Copy number analysis revealed a predominant pattern gains occurring clustering locus. general, encoding worse patient survival. gene did not necessarily correlate, high S100A4 poor Furthermore, integrated ex vivo sensitivity data showed significant negative correlation ( S100A8 , S100A9 S100A12 ) some drugs used current treatment, including proteasome inhibitors (bortezomib, carfilzomib, ixazomib) histone deacetylase inhibitor panobinostat. Combined proteomic pharmacological exhibited association (S100A4, S100A8, S100A9) Clinically, higher S100A10 significantly linked shorter free receiving carfilzomib-based therapy. results indicate an highlight potential functional importance on chromosome established drugs, inhibitors.
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: ['2296-634X']
DOI: https://doi.org/10.3389/fcell.2021.723016